Haematology & Stem Cell Transplant Centre
3 Mount Elizabeth
Mount Elizabeth Hospital Level 7
- MBBS, National University of Singapore
- Master of Medicine (Internal Medicine), National University of Singapore
- Fellow of the Academy of Medicine, Singapore
- Member of the American Society of Haematology
- Member of the European Haematology Association
- 1988, 1991 - Posted as special fellow to the Fred Hutchinson Cancer Centre in Seattle, USA for Bone Marrow Transplant and Transplant Immunology
- 1993 - Appointed Head of Department of Haematology, Singapore General Hospital
- 1995 - Appointed Chairman, Chapter of Haematology, Singapore Academy of Medicine
- 1995 - Appointed Clinical Associate Professor, National University of Singapore
- 1997 - Appointed Director of the National Blood Centre, Health Science Authority
- 2004 - Appointed Medical Director of the Haematology & Stem Cell Transplant Centre, Mount Elizabeth Hospital
- 2004 - Appointed as the first Medical Director of the Singapore Cord Blood Bank
- Dr Patrick Tan is considered a pioneer in the field of cord blood and stem cell transplant: he is credited with performing the world's first successful cases of unrelated blood stem cell transplant and unrelated cord blood transplant for Thalassemia Major, as well as the first successful cases of non-myeloablative double cord blood transplant for acute myeloid leukemia and unrelated non-myeloablative cord blood stem cell transplant for multiple myeloma. With the development of more cord blood banks across the world and a global network that allows access to the database, Dr Tan believes that chances of curing blood disorders and blood cancers are improving as the range of treatment available becomes greater.
- CASE STUDY 1 - Sibling Allogeneic Transplant: Mr H was diagnosed with Acute T Cell Lymphoblastic Leukemia with multiple cytogenetic abnormalities, a poor risk leukemia with a long term cure chance of less than 10% using conventional chemotherapy. He met Dr Patrick Tan in 2004 when he was 30 years old, and chose to undergo a Matched Sibling transplant with his younger sibling 1 month later. His bone marrow showed complete remissions after the transplant, and remains so after 11 years. Mr H married a few years ago, and his health has continued to perform well with good blood counts.
- CASE STUDY 2 - Unrelated Allogeneic Transplant: In 2011, Mr N was found to have Primary Myelofibrosis, a serious bone marrow disorder that disrupts the body's production of healthy blood cells. By the time he saw Dr Patrick Tan in 2012, his condition had deteriorated to advanced Myelofibrosis Stage 3, which was then uncurable with conventional treatment. As no matched sibling donor was available, a full matched unrelated volunteer donor was found on the Singapore Bone Marrow Donor Programme, and a transplant was carried out a few months later. Since then, Mr N has been recording normal blood counts and is currently doing well.
- CASE STUDY 3 - Autologous Transplant: After experiencing severe anaemia and fainting spells, Mr L was diagnosed as having Acute Myeloid Leukemia in 2008 at the age of 72. Told that he only had 3 months to live, Mr L came to see Dr Patrick Tan the following month. Bone marrow studies found a viable treatment plan, and Mr L was given induction chemotherapy that same month, followed by an autologous peripheral blood stem cell transplant 4 months later. Mr L's blood count recovered 10 days after the transplant and he was in full remission 3 months later. Now 79 years old, Mr L remains active and has had normal blood counts since his treatment with Dr Patrick Tan.
- CASE STUDY 4 - Cord Blood Transplant: Mr V was first diagnosed with Acute Myeloid Leukemia FAB M2 in 2005 at the age of 20, but by June 2006 he had already relapsed three times despite receiving chemotherapy in his home country. With no matched sibling donor and no volunteer unrelated donor available, he was rejected by bone marrow transplant in him home country and his outlook was very bleak by the time he came Singapore to see Dr Patrick Tan in November 2006. Dr Patrick Tan managed to find matching unrelated cord blood bank samples in the Australian Cord Blood Bank, and after using salvage chemotherapy to control his condition, an unrelated cord blood transplant was performed in January 2007. Mr V's leukemia showed complete remission 60 days after the transplant, and it has remained in remission for the last 8 years. Since his recovery, he has completed his university education and is currently working normally, with healthy blood counts.
- Excellence for Singapore Award 2002
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