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Mount Elizabeth Novena Centre for Genomic Health
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At the Mount Elizabeth Novena Centre for Genomic Health, we offer a comprehensive range of medical-grade genetic testing services that uses next-generation sequencing (NGS) to help you and your family uncover and understand any genetic mutations you may have with the goal of personalising medical care for each person.
Our clinical genetic tests are grouped into 3 categories: cancer, brain health, and heart health. These tests can help detect inherited conditions, guide preventive measures, and support personalised treatment planning.
We offer genetic tests to identify inherited cancer syndromes that may increase your risk for:
- Hereditary breast and ovarian cancer syndrome (HBOC)
- Lynch syndrome
- Gynaecologic cancers (ovarian, uterine/endometrial)
- Gastrointestinal cancers (colorectal, gastric, pancreatic)
- Endocrine cancers (thyroid, parathyroid, pituitary, adrenal glands)
- Genitourinary cancers (renal/urinary tract, prostate)
- Skin cancers (melanoma, basal cell carcinoma)
- Brain/nervous system cancers
Who should consider this test:
- One or more of your family members are diagnosed with the abovementioned cancers at age 50 or younger
- One or more members of your family are diagnosed with the abovementioned cancers. with an additional family history of other cancers, such as prostate cancer, melanoma, and pancreatic cancer
- If you have a rare or uncommon cancer
What the results can do for you:
- Allow for early cancer detection and intervention
- Identify at-risk family members for cascade screening
Our medical-grade tests can detect genetic conditions that may cause:
- Early onset stroke (e.g. Fabry disease, MELAS)
- Early onset dementia (e.g., Alzheimer’s disease, Parkinson’s disease, fronto-temporal dementia)
Who should consider this test:
- Individuals with unexplained white matter changes on brain imaging and a family history of stroke or vascular dementia
- Individuals with an unusually young diagnosis of stroke or dementia and a family history of these conditions
What the results can do for you:
- Clarify diagnosis and guide treatment choices
- Inform prognosis and identify suitable clinical trials
- Empower family members with preventive and monitoring strategies
- Provide emotional relief through clear answers
We provide genetic tests for hereditary heart conditions such as:
- Familial hypercholesterolaemia (FH)
- Hypertrophic cardiomyopathy
- Marfan syndrome
- Cardiomyopathy
- Channelopathy
- Aortopathy
Who should consider this test:
- Those with a family history of early cardiovascular disease or sudden unexplained death
- Males with a heart attack before age 50, or females before age 60
- Individuals with very high LDL cholesterol (> 6.5 mmol/L for children or > 5.2 mmol/L for adults)
- Those with physical signs of high cholesterol (e.g., swollen tendons, yellowish patches around the eyes)
What the results can do for you:
- Kickstart risk-reduction strategies with your doctor
- Identify at-risk family members for cascade screening
Next-generation sequencing (NGS) in genetic testing
Next-generation sequencing (NGS) is a powerful technique used to analyse genetic information with speed and precision.
NGS-based germline testing can identify inherited genetic variants associated with hereditary cancers, providing critical insights for highly tailored prevention or treatment strategies.
By identifying inherited genetic variants, these tests allow us to customise prevention and treatment plans based on your unique genetic predisposition, enhancing effectiveness and improving outcomes for hereditary cancers. NGS enables a deeper understanding of inherited cancer risks, supporting proactive health management and personalised care.
With NGS-powered testing, you gain valuable knowledge about your hereditary cancer risk, empowering you to make informed decisions and receive care tailored to your genetic profile.
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